HDOs are leveraging a combination of telehealth capabilities, such as remote patient monitoring (RPM) and videoconferencing, to treat patients in their homes. These modalities are used to treat numerous conditions, such as patients battling chronic illness or requiring postoperative monitoring. As use of these capabilities continues to grow, it is important to ensure that the infrastructure supporting them can maintain the confidentiality, integrity, and availability of patient data, and to ensure the safety of patients. It is also important to ensure the privacy of patient data by considering the privacy engineering objectives of predictability, manageability, and disassociability of data. The goal of this project is to provide a practical solution for securing the telehealth RPM ecosystem. The project team will perform a risk assessment on a representative RPM ecosystem in the laboratory environment, apply the NIST Cybersecurity Framework and guidance based on medical device standards, and collaborate with industry and public partners. This project will focus on the diagnostic aspects of remote patient monitoring. The project team will also create a reference design and a detailed description of the practical steps needed to implement a secure solution based on standards and best practices. This project will result in a freely available NIST Cybersecurity Practice Guide.